ON THE ISOLATION OF NERVE ENDINGS AND SYNAPTIC VESICLES

作者：Eduardo D. P. De Robertis, Amanda Pellegrino de Iraldi, G B Germán Rodríguez, Carlos J. Gómez · 发表于：The Journal of Cell Biology · 年份：1961 · DOI：10.1083/jcb.9.1.229 · 被引用次数：168 · 研究领域：Caveolin-1 and cellular processes、Lipid Membrane Structure and Behavior、Cellular transport and secretion

Since the first description of the "synaptic vesicles" (1, 2) the suggestion was made that they could be associated with acetylcholine and other chemical synaptic mediators. Later work gave further information about the possible composition of synaptic vesicles and their role in synaptic functions. It was shown that they degenerate very early in the nerve terminal after section of the axon (3), a finding that can be correlated with the decrease in transmitter content of the synapse (4, 5). It was also found that the synaptic vesicles of some of the retina synapses were reduced in size with disuse (6) and changed with dark adaptation and stimulation with light (7). Finally, striking