Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.

作者：D A Fisher, S. Hunt, Leroy Hood · 发表于：The Journal of Experimental Medicine · 年份：1985 · DOI：10.1084/jem.162.2.528 · 被引用次数：111 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Glycosylation and Glycoproteins Research、Advanced Proteomics Techniques and Applications

We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.