Production of a Broad Spectrum Antimicrobial Substance byLactobacillus reuteri

作者：Lars T. Axelsson, Tung‐Ching Chung, Walter J. Dobrogosz, Sven Lindgren · 发表于：Microbial Ecology in Health and Disease · 年份：1989 · DOI：10.3402/mehd.v2i2.7449 · 被引用次数：262 · 研究领域：Probiotics and Fermented Foods、Protein Hydrolysis and Bioactive Peptides、Microbial Metabolites in Food Biotechnology

Lactobacillus reuteri resides in the gastrointestinal tract of humans, swine, poultry and other animals. Resting cells of this species convert glycerol into a potent, broad-spectrum antimicrobial substance termed reuterin. Reuterin is a low molecular weight, neutral, water soluble compound, capable of inhibiting growth of species representing all bacterial genera tested thus far, including: Escherichia, Salmonella, Shigella, Proteus, Pseudomonas, Clostridium and Staphylococcus. Also affected, but to a lesser degree, are lactic acid bacteria belonging to the genera Streptococcus, Pediococcus, Leuconostoc, and Lactobacillus. In this report we describe a method to screen lactobacilli for production of unique antimicrobial substances and the discovery of reuterin.