Association of vitamin D receptor gene polymorphism with the risk of renal cell carcinoma: a meta-analysis

作者：Chao Ou, Huiliu Zhao, Bo Zhu, Huang Ling-sha, Peizhang Li, Lao Ming · 发表于：Journal of Receptors and Signal Transduction · 年份：2014 · DOI：10.3109/10799893.2014.919593 · 被引用次数：24 · 研究领域：Vitamin D Research Studies、Folate and B Vitamins Research、Pharmacological Effects and Toxicity Studies

Relationship between vitamin D receptor (VDR) gene polymorphism and the risk of renal cell carcinoma from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphism and the risk of renal cell carcinoma using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 March 2014, and eligible investigations were included and synthesized using meta-analysis method. Five reports were recruited into this meta-analysis for the association of VDR gene polymorphism with renal cell carcinoma susceptibility. In this meta-analysis, the ApaI AA genotype, BsmI BB genotype, Fok1 f allele, and Fok1 FF genotype were associated with the risk of renal cell carcinoma in Asians. However, VDR ApaI, BsmI, TaqI, and Fok1 gene polymorphism were not associated with the risk of renal cell carcinoma in overall populations and in Caucasians. In conclusion, the ApaI AA genotype, BsmI BB genotype, Fok1 f allele, and Fok1 FF genotype were associated with the risk of renal cell carcinoma in Asians. However, more studies should be conducted to confirm it.