Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies

作者：Carole Hart, David Stewart Morrison, George David Batty, Richard Mitchell, George Davey Smith · 发表于：BMJ · 年份：2010 · DOI：10.1136/bmj.c1240 · 被引用次数：427 · 研究领域：Alcohol Consumption and Health Effects、Liver Disease Diagnosis and Treatment、Substance Abuse Treatment and Outcomes

OBJECTIVE: To investigate whether alcohol consumption and raised body mass index (BMI) act together to increase risk of liver disease. DESIGN: Analysis of data from prospective cohort studies. SETTING: Scotland. PARTICIPANTS: Data were from two of the Midspan prospective cohort studies (9559 men): "Main" study 1965-8, participants from workplaces across central belt of Scotland, population of island of Tiree, and mainland relatives, and "Collaborative" study, 1970-3, participants from 27 workplaces in Glasgow, Clydebank, and Grangemouth. Follow-up was to 31 December 2007 (median 29 years, range 0.13-42). We divided participants into nine groups based on measures of body mass index (BMI) (underweight/normal weight <25, overweight 25 to <30, and obese >or=30) and alcohol consumption (none, 1-14, and >or=15 units per week). MAIN OUTCOME MEASURES: Liver disease morbidity and mortality. RESULTS: 80 (0.8%) men died with liver disease as the main cause and 146 (1.5%) with liver disease as any cause. In the Collaborative study, 196 men (3.3%) had liver disease defined by a death, admission, or cancer registration. BMI and alcohol consumption were strongly associated with liver disease mortality in analyses adjusted for other confounders (P=0.001 and P<0.0001 respectively). Drinkers of 15 or more units per week in any BMI category and obese drinkers had raised relative rates for all definitions of liver disease, compared with underweight/normal weight non-drinkers. Drinkers of 15 or m...