Antimicrobial Periodontal Treatment Decreases Serum C‐Reactive Protein, Tumor Necrosis Factor‐Alpha, But Not Adiponectin Levels in Patients with Chronic Periodontitis

作者：Yoshihiro Iwamoto, Fusanori Nishimura, Yoshihiko Soga, Kazu Takeuchi, Mikinao Kurihara, Shogo Takashiba, Yoji Murayama · 发表于：Journal of Periodontology · 年份：2003 · DOI：10.1902/jop.2003.74.8.1231 · 被引用次数：172 · 研究领域：Oral microbiology and periodontitis research、Adipokines, Inflammation, and Metabolic Diseases、Bone Metabolism and Diseases

BACKGROUND: Elevated levels of C-reactive protein (CRP) and decreased plasma adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent observations suggested that adiponectin and tumor necrosis factor-alpha (TNF-alpha) suppressed each other's production. Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-alpha levels. METHODS: Fifteen chronic periodontitis patients with various systemic conditions at high risk for atherosclerosis were enrolled in the study. Patients were non-surgically treated with topical application of antibiotics and mechanical debridement of calculus once a week for 1 month. Before and after therapy, CRP, adiponectin, and TNF-alpha levels were measured. RESULTS: Both CRP and TNF-alpha levels were significantly decreased after treatment (P<0.01 and P<0.03, respectively), while adiponectin levels did not change significantly. CONCLUSIONS: Periodontal treatment is effective in reducing CRP and TNF-alpha, while adiponectin does not appear to be influenced by periodontal treatment. Elevated levels of CRP and TNF-alpha may be associated with increased risk for future development of atherosclerosis in periodontitis patients.