Large-scale assignment of orthology: back to phylogenetics?

作者：Toni Gabaldón · 发表于：Genome biology · 年份：2008 · DOI：10.1186/gb-2008-9-10-235 · 被引用次数：212 · 研究领域：Genomics and Phylogenetic Studies、Evolution and Paleontology Studies、Biomedical Text Mining and Ontologies

Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.