Peroxisome Biogenesis Disorders

作者：Sabine Weller, Stephen John Gould, David Valle · 发表于：Annual Review of Genomics and Human Genetics · 年份：2003 · DOI：10.1146/annurev.genom.4.070802.110424 · 被引用次数：204 · 研究领域：Peroxisome Proliferator-Activated Receptors、Cancer-related gene regulation、RNA modifications and cancer

The peroxisome biogenesis disorders (PBDs) comprise 12 autosomal recessive complementation groups (CGs). The multisystem clinical phenotype varies widely in severity and results from disturbances in both development and metabolic homeostasis. Progress over the last several years has lead to identification of the genes responsible for all of these disorders and to a much improved understanding of the biogenesis and function of the peroxisome. Increasing availability of mouse models for these disorders offers hope for a better understanding of their pathophysiology and for development of therapies that might especially benefit patients at the milder end of the clinical phenotype.