Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

作者：Lisa M. Coussens, Teresa L. Yang‐Feng, Yu-Cheng Liao, Ellson Chen, Alane Gray, John P. McGrath, Peter H. Seeburg, Towia Aron Libermann, Joseph Schlessinger, Uta Francke, Arthur D. Levinson, Axel Ullrich · 发表于：Science · 年份：1985 · DOI：10.1126/science.2999974 · 被引用次数：1827 · 研究领域：HER2/EGFR in Cancer Research、Chemical Synthesis and Analysis、Monoclonal and Polyclonal Antibodies Research

A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product; the chromosomal location of the gene for this protein is coincident with the neu oncogene, which suggests that the two genes may be identical.