Cyclic changes in serum cholesterol and lipoproteins following different doses of combined postmenopausal hormone replacement therapy

作者：Jytte Jensen, Lisbeth Nilas, Claus Christiansen · 发表于：BJOG An International Journal of Obstetrics & Gynaecology · 年份：1986 · DOI：10.1111/j.1471-0528.1986.tb08035.x · 被引用次数：102 · 研究领域：Menopause: Health Impacts and Treatments、Hormonal and reproductive studies、Estrogen and related hormone effects

Cyclic changes in lipoproteins after sequential oestrogen-progestogen therapy were studied in a group of healthy postmenopausal women treated with three different hormone doses, and followed up for two consecutive cycles by twice weekly examinations (a total of 17 examinations). There was a significant rise in high density lipoprotein (HDL) cholesterol and a significant fall in low density lipoprotein (LDL) cholesterol closely related to the dose of the oestrogen component. Addition of the progestogen, 1 mg of norethisterone acetate, decreased the oestrogen-induced rise in HDL, but HDL levels remained higher than initial values in the high-dose (4 mg) and medium dose (2 mg) groups. The average increases in HDL cholesterol were 13%, 9% and 2% in the high-dose, medium-dose and low-dose (1 mg) groups, respectively, and the corresponding mean decreases in LDL cholesterol were 18%, 15% and 10% respectively. We conclude that postmenopausal treatment with sequentially combined oestrogen-progestogen has no adverse effects on the lipoprotein status.