Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality

作者：John Danesh, Sarah Lewington, Simon G Thompson, Gordon D O Lowe, Rory Collins, J B Kostis, A. C. Wilson, A R Folsom, K Wu, M. Benderly, U Goldbourt, Johann Willeit, S Kiechl, J W G Yarnell, P M Sweetnam, P C Elwood, M. Cushman, Bruce M. Psaty, R P Tracy, A Tybjaerg-Hansen, F Haverkate, Moniek P.M. de Maat, F G R Fowkes, A J Lee, Felicity B. Smith, Veikko V Salomaa, K Harald, R Rasi, E Vahtera, P Jousilahti, J Pekkanen, R D'Agostino, W B Kannel, Pwf Wilson, GH Tofler, Carmen Luisa Arocha-Piñango, A Rodriguez-Larralde, E Nagy, M Mijares, R Espinosa, E Rodriquez-Roa, E Ryder, M P Diez-Ewald, G Campos, V Fernandez, E Torres, R Marchioli, Franco Valagussa, A Rosengren, L Wilhelmsen, G Lappas, H Eriksson, P Cremer, D Nagel, J. David Curb, B Rodriguez, K Yano, Jukka T. Salonen, K Nyyssönen, TP Tuomainen, Bo Hedblad, P Lind, H Loewel, W Koenig, T W Meade, J.A. Cooper, B De Stavola, C Knottenbelt, G J Miller, J.A. Cooper, K A Bauer, R.D. Rosenberg, S Sato, A. Kitamura, Y. Naito, T. Palosuo, P Ducimetiere, Philippe Amouyel, D Arveiler, A E Evans, J Ferrieres, Irène Juhan-Vague, A Bingham, H. Schulte, G Assmann, B. Cantin, B. Lamarche, JP Després, G R Dagenais, H Tunstall-Pedoe, M Woodward, Y Ben-Shlomo, G Davey Smith, V. Palmieri, Jeun-Liang Yeh, AR Rudnicka, P Ridker, F Rodeghiero, A. Tosetto, J. Shepherd, I Ford, M Robertson, E Brunner, M Shipley, E J M Feskens, Daan Kromhout, A Dickinson, B Ireland, Kelsey Juzwishin, S Kaptoge, S. Lewington, A Memon, N. Sarwar, M Walker, J. Wheeler, I. White, A Wood · 发表于：JAMA · 年份：2005 · DOI：10.1001/jama.294.14.1799 · 被引用次数：1116 · 研究领域：Blood properties and coagulation、Inflammatory Biomarkers in Disease Prognosis、Cardiovascular Health and Disease Prevention

CONTEXT: Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke. OBJECTIVE: To assess the relationships of fibrinogen levels with risk of major vascular and with risk of nonvascular outcomes based on individual participant data. DATA SOURCES: Relevant studies were identified by computer-assisted searches, hand searches of reference lists, and personal communication with relevant investigators. STUDY SELECTION: All identified prospective studies were included with information available on baseline fibrinogen levels and details of subsequent major vascular morbidity and/or cause-specific mortality during at least 1 year of follow-up. Studies were excluded if they recruited participants on the basis of having had a previous history of cardiovascular disease; participants with known preexisting CHD or stroke were excluded. DATA EXTRACTION: Individual records were provided on each of 154,211 participants in 31 prospective studies. During 1.38 million person-years of follow-up, there were 6944 first nonfatal myocardial infarctions or stroke events and 13,210 deaths. Cause-specific mortality was generally available. Analyses involved proportional hazards modeling with adjustment for confounding by known cardiovascular risk factors and for regression dilution bias. DATA SYNTHESIS: Within each age group considered (40-59, 60-69, and > or =70 years), there was an approximately log-linear association with usual fibrinogen level for the risk o...