World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies for the Use of Antimicrobials in Food Production Animals

作者：Peter Collignon, John H. Powers, Tom Chiller, Awa Aïdara‐Kane, Frank M. Aarestrup · 发表于：Clinical Infectious Diseases · 年份：2009 · DOI：10.1086/599374 · 被引用次数：391 · 研究领域：Antibiotic Resistance in Bacteria、Pharmaceutical and Antibiotic Environmental Impacts、Antibiotics Pharmacokinetics and Efficacy

The use of antimicrobials in food animals creates an important source of antimicrobial-resistant bacteria that can spread to humans through the food supply.Improved management of the use of antimicrobials in food animals, particularly reducing the usage of those that are "critically important" for human medicine, is an important step toward preserving the benefits of antimicrobials for people.The World Health Organization has developed and applied criteria to rank antimicrobials according to their relative importance in human medicine.Clinicians, regulatory agencies, policy makers, and other stakeholders can use this ranking when developing risk management strategies for the use of antimicrobials in food production animals.The ranking allows stakeholders to focus risk management efforts on drugs used in food animals that are the most important to human medicine and, thus, need to be addressed most urgently, such as fluoroquinolones, macrolides, and third-and fourth-generation cephalosporins.Antimicrobials decrease morbidity and mortality associated with serious and life-threatening infections.Antimicrobial resistance decreases the effectiveness of these drugs, increasing the risk of morbidity and mortality in serious diseases and, thus, compromising human health [1][2][3][4][5][6].Antimicrobial resistance is an inevitable consequence of antimicrobial use.Poverty; suboptimal control of the sale, quality, and use of antimicrobials; and poor sewage and water systems are factors ...