The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012

作者：Teresa K. Attwood, Alain Coletta, G. J. Muirhead, Athanasia Pavlopoulou, Penny Philippou, Ilya Popov, Carlos Romá‐Mateo, Athina Theodosiou, Alex Mitchell · 发表于：Database · 年份：2012 · DOI：10.1093/database/bas019 · 被引用次数：178 · 研究领域：Machine Learning in Bioinformatics、Biomedical Text Mining and Ontologies、Advanced Proteomics Techniques and Applications

The PRINTS database, now in its 21st year, houses a collection of diagnostic protein family 'fingerprints'. Fingerprints are groups of conserved motifs, evident in multiple sequence alignments, whose unique inter-relationships provide distinctive signatures for particular protein families and structural/functional domains. As such, they may be used to assign uncharacterized sequences to known families, and hence to infer tentative functional, structural and/or evolutionary relationships. The February 2012 release (version 42.0) includes 2156 fingerprints, encoding 12 444 individual motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. Here, we report the current status of the database, and introduce a number of recent developments that help both to render a variety of our annotation and analysis tools easier to use and to make them more widely available. Database URL: www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/.