QMSim: a large-scale genome simulator for livestock

作者：Mehdi Sargolzaei, Flávio S. Schenkel · 发表于：Bioinformatics · 年份：2009 · DOI：10.1093/bioinformatics/btp045 · 被引用次数：403 · 研究领域：Genetic and phenotypic traits in livestock、Genetic Mapping and Diversity in Plants and Animals、Genetic Associations and Epidemiology

SUMMARY: QMSim was designed to simulate large-scale genotyping data in multiple and complex livestock pedigrees. The simulation is basically carried out in two steps. In the first step, a historical population is simulated to establish mutation-drift equilibrium, and in the second step, recent population structures are generated, which can be very complex. A wide variety of genome architectures, ranging from infinitesimal model to single-locus model, can be simulated. The program is efficient in terms of computing time and memory requirements. AVAILABILITY: Executable versions of QMSim for Windows and Linux are freely available at http://www.aps.uoguelph.ca/~msargol/qmsim/.