Esophageal and Gastric Cardia Cancers on 4238 Chinese Patients Residing in Municipal and Rural Regions: A Histopathological Comparison During 24‐Year Period

作者：Yu Fan, Xin Song, Ji Lin Li, Xue Min Li, Bin Liu, Ran Wang, Zong Min Fan, Lidong Wang · 发表于：World Journal of Surgery · 年份：2008 · DOI：10.1007/s00268-008-9674-x · 被引用次数：42 · 研究领域：Esophageal Cancer Research and Treatment、Eosinophilic Esophagitis、Gastric Cancer Management and Outcomes

BACKGROUND: Nutrition deficiencies or poverty traditionally have been recognized to be related with increased risk for esophageal cancer (EC) in rural regions at junction of Henan, Hebei, and Shanxi provinces in northern China--the highest incidence area for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA). Since the 1980s, economic and nutrition condition in these areas have been improved greatly. However, the histopathological types, staging pattern, and occurrence of ESCC and GCA, especially for esophageal adenocarcinoma (EAC), which have been rarely examined in the Chinese population during the past decades in these areas have not been well characterized to date. METHODS: Yearly diagnosed new esophageal cancer (ESCC and EAC) and GCA patients from Beijing Tongren Hospital (in municipal low-risk region) and Cixian People Hospital (in rural high-risk region) during 24-year period (1982-2005) were studied retrospectively. Only local resident patients with surgical resection were included. Age at diagnosis, tumor stage and site, and histopathological pattern were recorded for each patient from the tumor registry database in these hospitals. RESULTS AND CONCLUSIONS: This study demonstrated that the common ESCC sites were different in municipal (chiefly in lower third of the esophagus) and in rural (chiefly in middle third of the esophagus) regions. The peak age of ESCC, EAC, and GCA patients in rural region was 10 years younger than in municipal...