Recognition of Sialylated Poly‐N‐acetyllactosamine Chains on N‐ and O‐Linked Glycans by Human and Avian Influenza A Virus Hemagglutinins

作者：Corwin M. Nycholat, Ryan McBride, Damian C. Ekiert, Rui Xu, Janani Rangarajan, Wenjie Peng, Nahid Razi, Michel Gilbert, Warren W. Wakarchuk, Ian A. Wilson, James C. Paulson · 发表于：Angewandte Chemie International Edition · 年份：2012 · DOI：10.1002/anie.201200596 · 被引用次数：95 · 研究领域：Influenza Virus Research Studies、Glycosylation and Glycoproteins Research、Monoclonal and Polyclonal Antibodies Research

Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.