Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites

作者：Feza Korkusuz, Atsushi Uchida, Yoshitaka Shinto, Naoya Araki, Kazunori Inoue, Katsuhiko Ono · 发表于：Journal of Bone and Joint Surgery - British Volume · 年份：1993 · DOI：10.1302/0301-620x.75b1.8380599 · 被引用次数：117 · 研究领域：Bone Tissue Engineering Materials、Orthopaedic implants and arthroplasty、Orthopedic Infections and Treatments

The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implant-related osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combination with antibiotic-impregnated acrylic bone cement, all failed to eradicate the infections.