Mouse Genome Informatics (MGI): reflecting on 25 years

作者：Janan T. Eppig, Joel E. Richardson, James A. Kadin, Martin Ringwald, Judith A. Blake, Carol J. Bult · 发表于：Mammalian Genome · 年份：2015 · DOI：10.1007/s00335-015-9589-4 · 被引用次数：62 · 研究领域：Biomedical Text Mining and Ontologies、Gene expression and cancer classification、Genetics, Bioinformatics, and Biomedical Research

From its inception in 1989, the mission of the Mouse Genome Informatics (MGI) resource remains to integrate genetic, genomic, and biological data about the laboratory mouse to facilitate the study of human health and disease. This mission is ever more feasible as the revolution in genetics knowledge, the ability to sequence genomes, and the ability to specifically manipulate mammalian genomes are now at our fingertips. Through major paradigm shifts in biological research and computer technologies, MGI has adapted and evolved to become an integral part of the larger global bioinformatics infrastructure and honed its ability to provide authoritative reference datasets used and incorporated by many other established bioinformatics resources. Here, we review some of the major changes in research approaches over that last quarter century, how these changes are reflected in the MGI resource you use today, and what may be around the next corner.