t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34

作者：Mathijs Baens, José Luis Ferreiro, Thomas Tousseyn, Helena Urbánková, Lucienne Michaux, Laurence de Leval, Daan Dierickx, Pascal Wolter, Xavier Sagaert, Peter Vandenberghe, C. De Wolf‐Peeters, Iwona Włodarska · 发表于：Haematologica · 年份：2011 · DOI：10.3324/haematol.2011.052639 · 被引用次数：47 · 研究领域：Lymphoma Diagnosis and Treatment、Immune Cell Function and Interaction、Cancer Immunotherapy and Biomarkers

Genetic events underlying pathogenesis of nodal and extranodal marginal zone lymphoma are not completely understood. We report here a novel t(X;14)(p11.4;q32.33) identified in 4 lymphoma cases: 2 with a mucosa-associated lymphoid tissue lymphoma, one with a nodal marginal zone lymphoma and one with gastric diffuse large B-cell lymphoma. In all cases, lymphoma evolved from a previous auto-immune disorder. Fluorescence in situ hybridization and molecular studies showed that t(X;14), which is mediated by immunoglobulin heavy chain locus, targets the GPR34 gene at Xp11.4. Upregulation of GPR34 mRNA and aberrant expression of GPR34 protein has been demonstrated in 3 presented cases by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. GPR34 belongs to the largest family of cell surface molecules involved in signal transmission that play important roles in many physiological and pathological processes, including tumorigenesis. Although functional consequences of t(X;14) have not been identified, our studies suggest that up-regulated GPR34 activate neither nuclear factor-κB nor ELK-related tyrosine kinase.