Warfarin resistance and vitamin K requirement in the rat

作者：J. H. Greaves, Priscilla Ayres · 发表于：Laboratory Animals · 年份：1973 · DOI：10.1258/002367773781008614 · 被引用次数：49 · 研究领域：Vitamin K Research Studies、Pharmacogenetics and Drug Metabolism

The development of vitamin K deficiency, vitamin K requirement and warfarin susceptibility were studied in several types of warfarin-resistant and non-resistant rat. Domesticated HW strain rats needed about 13 times as much vitamin K 1 as did Wistar rats to maintain normal blood-clotting function, while HS strain rats were intermediate in this and in their susceptibility to warfarin. The vitamin K requirement of Wistar hybrids resembled that of the Wistar parent or was intermediate. Hypoprothrom-binaemia was induced at least as readily in non-resistant wild rats as in HS rats. A new diet suitable for inducing vitamin K deficiency in conventionally maintained Wistar rats is described, and it is suggested that the HW strain could be used for vitamin K bioassay. The genetical basis of warfarin resistance is discussed.