Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

作者：Valerie Mermall, Penny L. Post, Mark S. Mooseker · 发表于：Science · 年份：1998 · DOI：10.1126/science.279.5350.527 · 被引用次数：653 · 研究领域：Cardiomyopathy and Myosin Studies、Muscle Physiology and Disorders、Cardiovascular Effects of Exercise

In the past few years genetic, biochemical, and cytolocalization data have implicated members of the myosin superfamily of actin-based molecular motors in a variety of cellular functions including membrane trafficking, cell movements, and signal transduction. The importance of myosins is illustrated by the identification of myosin genes as targets for disease-causing mutations. The task at hand is to decipher how the multitude of myosins function at both the molecular and cellular level-a task facilitated by our understanding of myosin structure and function in muscle.