Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation

作者：Eric Chern-Pin Chua, Sing Chen Yeo, Ivan Tian-Guang Lee, Luuan-Chin Tan, Pauline Lau, Sara Shuhui Tan, Ivan Ho Mien, Joshua J. Gooley · 发表于：Physiological Reports · 年份：2014 · DOI：10.14814/phy2.12129 · 被引用次数：38 · 研究领域：Sleep and Work-Related Fatigue、Heart Rate Variability and Autonomic Control、Sleep and related disorders

Some individuals show severe cognitive impairment when sleep deprived, whereas others are able to maintain a high level of performance. Such differences are stable and trait-like, but it is not clear whether these findings generalize to physiologic responses to sleep loss. Here, we analyzed individual differences in behavioral and physiologic measures in healthy ethnic-Chinese male volunteers (n = 12; aged 22-30 years) who were kept awake for at least 26 h in a controlled laboratory environment on two separate occasions. Every 2 h, sustained attention performance was assessed using a 10-min psychomotor vigilance task (PVT), and sleepiness was estimated objectively by determining percentage eyelid closure over the pupil over time (PERCLOS) and blink rate. Between-subject differences in heart rate and its variability, and electroencephalogram (EEG) spectral power were also analyzed during each PVT. To assess stability of individual differences, intraclass correlation coefficients (ICC) were determined using variance components analysis. Consistent with previous work, individual differences in PVT performance were reproducible across study visits, as were baseline sleep measures prior to sleep deprivation. In addition, stable individual differences were observed during sleep deprivation for PERCLOS, blink rate, heart rate and its variability, and EEG spectral power in the alpha frequency band, even after adjusting for baseline differences in these measures (range, ICC = 0.67-0.9...