In vivo induction of tight junction proliferation in rat liver.

作者：Roberto Montesano, Giulio Gabbiani, Alain Perrelet, Lelio Orci · 发表于：The Journal of Cell Biology · 年份：1976 · DOI：10.1083/jcb.68.3.793 · 被引用次数：87 · 研究领域：Barrier Structure and Function Studies、Drug Transport and Resistance Mechanisms、Biochemical effects in animals

The chronic administration of phalloidin induces an extensive development of tight junctions between rat hepatocytes. The junctional strands lose their predominantly parallel orientation with respect to the canalicular lumen and extend abluminally in irregular patterns which cover large membrane areas at considerable distance from the bile canaliculi. These changes indicate both proliferation and provide further evidence that these junctions are not permanent differentiations of the cell membrane.