Pulmonary Fissure Integrity and Collateral Ventilation in COPD Patients

作者：Jiantao Pu, Zhimin Wang, Suicheng Gu, Carl R. Fuhrman, Joseph K. Leader, Xin Meng, John Tedrow, Frank C. Sciurba · 发表于：PLoS ONE · 年份：2014 · DOI：10.1371/journal.pone.0096631 · 被引用次数：46 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Pleural and Pulmonary Diseases、Respiratory Support and Mechanisms

PURPOSE: To investigate whether the integrity (completeness) of pulmonary fissures affects pulmonary function in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A dataset consisting of 573 CT exams acquired on different subjects was collected from a COPD study. According to the global initiative for chronic obstructive lung disease (GOLD) criteria, these subjects (examinations) were classified into five different subgroups, namely non-COPD (222 subjects), GOLD-I (83 subjects), GOLD-II (141 subjects), GOLD-III (63 subjects), and GOLD-IV (64 subjects), in terms of disease severity. An available computer tool was used to aid in an objective and efficient quantification of fissure integrity. The correlations between fissure integrity, and pulmonary functions (e.g., FEV1, and FEV1/FVC) and COPD severity were assessed using Pearson and Spearman's correlation coefficients, respectively. RESULTS: For the five sub-groups ranging from non-COPD to GOLD-IV, the average integrities of the right oblique fissure (ROF) were 81.8%, 82.4%, 81.8%, 82.8%, and 80.2%, respectively; the average integrities of the right horizontal fissure (RHF) were 62.6%, 61.8%, 62.1%, 62.2%, and 62.3%, respectively; the average integrities of the left oblique fissure (LOF) were 82.0%, 83.2%, 81.7%, 82.0%, and 78.4%, respectively; and the average integrities of all fissures in the entire lung were 78.0%, 78.6%, 78.1%, 78.5%, and 76.4%, respectively. Their Pearson correlation coeff...