Clinical diagnosis of Alzheimer's disease

作者：Guy M. McKhann, David A. Drachman, Marshall Folstein, Robert Katzman, Donald D. Price, Emanuel M. Stadlan · 发表于：Neurology · 年份：1984 · DOI：10.1212/wnl.34.7.939 · 被引用次数：28075 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Traumatic Brain Injury and Neurovascular Disturbances

Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.