Building Muscle: Molecular Regulation of Myogenesis

作者：C. Florian Bentzinger, Yu Xin Wang, Michael A. Rudnicki · 发表于：Cold Spring Harbor Perspectives in Biology · 年份：2012 · DOI：10.1101/cshperspect.a008342 · 被引用次数：1201 · 研究领域：Muscle Physiology and Disorders、Genetic Neurodegenerative Diseases、Genetics, Aging, and Longevity in Model Organisms

The genesis of skeletal muscle during embryonic development and postnatal life serves as a paradigm for stem and progenitor cell maintenance, lineage specification, and terminal differentiation. An elaborate interplay of extrinsic and intrinsic regulatory mechanisms controls myogenesis at all stages of development. Many aspects of adult myogenesis resemble or reiterate embryonic morphogenetic episodes, and related signaling mechanisms control the genetic networks that determine cell fate during these processes. An integrative view of all aspects of myogenesis is imperative for a comprehensive understanding of muscle formation. This article provides a holistic overview of the different stages and modes of myogenesis with an emphasis on the underlying signals, molecular switches, and genetic networks.