DNA-binding properties of nuclear matrix proteins

作者：David E. Comings, Alice S. Wallack · 发表于：Journal of Cell Science · 年份：1978 · DOI：10.1242/jcs.34.1.233 · 被引用次数：51 · 研究领域：Nuclear Structure and Function、RNA Research and Splicing、Genomics and Chromatin Dynamics

Mouse nuclear matrix proteins, examined by a filter assay, were found to bind to DNA. There was no preference for homologous mouse compared to heterologous E. coli DNA. Competition assays showed a preference for AT-rich DNA and of the 4 single-stranded homopolymers there was a preference for poly(dT). These observations are consistent with the possibility that the matrix may play a role in the formation of AT-rich chromomeres (G-bands).