Whole Body 18FDG-PET and the Response of Esophageal Cancer to Induction Therapy: Results of a Prospective Trial

作者：Robert J. Downey, Tim J. Akhurst, David H. Ilson, Robert J. Ginsberg, Manjit S. Bains, Mithat Gönen, Heng Nung Koong, Marc Jeffrey Gollub, Bruce Daniel Minsky, Maureen Frances Zakowski, Alan D. Turnbull, Steven M. Larson, Valerie W. Rusch · 发表于：Journal of Clinical Oncology · 年份：2003 · DOI：10.1200/jco.2003.04.013 · 被引用次数：321 · 研究领域：Esophageal Cancer Research and Treatment、Medical Imaging Techniques and Applications、Pancreatic and Hepatic Oncology Research

PURPOSE: Whole-body 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) imaging before and after induction therapy was prospectively evaluated in patients with esophageal cancer to determine whether changes in PET images could measure response to therapy. PATIENTS AND METHODS: Between April 1997 and April 1999, 39 patients (34 men and five women; median age, 59 years; range, 36 to 76 years) with esophageal cancer were prospectively enrolled in a single-institution clinical trial of staging, including PET, induction therapy, restaging including PET, and esophagectomy. All patients undergoing esophagectomy after induction therapy (n = 17) were followed either to recurrence, to death, or through a disease-free interval of at least 24 months. RESULTS: PET after standard staging studies and before therapy imaged undetected sites of metastatic disease in six patients (15%). Restaging (including PET) after induction therapy did not identify any patients with disease progression or any patients with loco-regionally unresectable disease at exploration. The median decrease in the standardized uptake value (SUV) during induction therapy was 59%. After R0 esophagectomy, the 2-year disease-free and overall survival was 38% and 63%, respectively, among patients who had a less than 60% decrease in SUV, and 67% and 89%, respectively, among patients who had a greater than 60% decrease in SUV (P =.055 and P =.088, respectively). CONCLUSION: Compared with conventional imaging, ...