A study of the interaction of roxithromycin with theophylline and carbarmazepine

作者：Béatrice Saint–Salvi, Dominique Tremblay, A. Surjus, Marc André Lefebvre · 发表于：Journal of Antimicrobial Chemotherapy · 年份：1987 · DOI：10.1093/jac/20.suppl_b.121 · 被引用次数：45 · 研究领域：Coordination Chemistry and Organometallics、Epilepsy research and treatment、Asymmetric Synthesis and Catalysis

There have been reports of an interaction when theophylline and macrolides are given together, and also when carbamazepine is given with macrolides. We compared the kinetics of theophylline and carbamazepine, given alone and then in combination with roxithromycin. Roxithromycin had little effect on the pharmacokinetics of theophylline and none on carbamazepine, and roxithromycin can be given with either of the drugs without any need to alter the dose.