Antibiotic resistance pattern of Pseudomonas aeruginosa isolated from patients of lower respiratory tract infection

作者：Tripathi Piyush, Banerjee Gopa, Saxena Shivani, Kumar Gupta Mahendra, Peng Wu · 发表于：African Journal of Microbiology Research · 年份：2011 · DOI：10.5897/ajmr11.460 · 被引用次数：28 · 研究领域：Antibiotic Use and Resistance、Inhalation and Respiratory Drug Delivery、Respiratory and Cough-Related Research

The aim of this study was to determine the antibiotic susceptibility pattern of Pseudomonas aeruginosa from sputum samples of lower respiratory tract infection (LRTI) patients admitted to the Department of Pediatrics and Pulmonary Medicine and also to update clinicians on various antimicrobial alternatives available in treatments. Sputum samples from 298 patients were cultured identified and antibiotic sensitivity was performed by standard methods. Out of the 298 sputum samples from LRTI patients 102 (34.23%) patients had established P. aeruginosa aetiology. Cefepime and ceftazidime show more resistance to P. aeruginosa isolates with resistance 36.27 and 35.30%, respectively. Least resistance was noted for piperacillin/tazobactam and Imipenam that is, 4.90 and 5.88%, respectively. Fifty percent P. aeruginosa are intermediate or marginally sensitive to gentamycin. Piperacillin/Tazobactam and Imipenam was found to be the most sensitive drug against P. aeruginosa in LRTI patients. Gentamycin resistance is continuously increasing.   Key words: Antibiotic susceptibility profile of P. aeruginosa, lower respiratory tract infection, multiple antibiotic resistance.