Characteristic analysis of α-fetoprotein-producing gastric carcinoma in China

作者：Xiaodong Li, Changping Wu, Mei Ji, Jun Wu, Binfeng Lu, Hongbing Shi, Jingting Jiang · 发表于：World Journal of Surgical Oncology · 年份：2013 · DOI：10.1186/1477-7819-11-246 · 被引用次数：37 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、Ovarian cancer diagnosis and treatment、Cancer-related molecular mechanisms research

α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer. The largest population of patients with AFPGC is found in China. In the present study, a total of 4,779 GC patients, including 317 AFPGC patients, from 11 clinical studies in China with a general AFPGC/GC ratio of 6.63% were summarized and analyzed. On the basis of analysis of the clinical data, the patients with AFPGC had larger tumor size, weaker cell differentiation, worse histopathological types, deeper serosal infiltration, more lymph node and liver metastases, poorer stages, shorter survival time and more positive expression of vascular endothelial growth factors than the patients without AFPGC. Our observation is consistent with previous results reported in studies of AFPGC. Overall, AFPGC is a subtype of GC with a poor prognosis.