Enantioselective Copper‐Catalyzed Decarboxylative Propargylic Alkylation of Propargylic Esters with β‐Keto Acids

作者：Fu‐Lin Zhu, Yahui Wang, De‐Yang Zhang, Xin‐Hu Hu, Xin‐Hu Hu, Song Chen, Chuan‐Jin Hou, Jie Xu, Xiang‐Ping Hu, Xiang‐Ping Hu · 发表于：Advanced Synthesis & Catalysis · 年份：2014 · DOI：10.1002/adsc.201400218 · 被引用次数：60 · 研究领域：Catalytic Alkyne Reactions、Catalytic C–H Functionalization Methods、Asymmetric Synthesis and Catalysis

Abstract The first copper‐catalyzed intermolecular enantioselective decarboxylative propargylic alkylation of propargylic esters with β‐keto acids as surrogates of ketones has been successfully developed by using a ketimine P,N,N‐ligand. High yields and excellent enantioselectivities (up to 98% ee ) have been achieved under the mild reaction conditions. magnified image