Evidence for Two Regions in the MousetComplex Controlling Transmission Ratios

作者：Józefa Styrna, Jan Klein · 发表于：Genetics Research · 年份：1981 · DOI：10.1017/s0016672300020632 · 被引用次数：38 · 研究领域：Genetic Mapping and Diversity in Plants and Animals、Genetic diversity and population structure、Chromosomal and Genetic Variations

SUMMARY Four newthaplotypes,tTu1throughtTu4, are described, three of them derived from thetw12tfhaplotype and one (tTu4) from thetw2haplotype. ThetTu1andtTu4haplotypes cause taillessness inT/tTu1orT/tTu4heterozygotes, lack the lethality factor, weakly suppress recombination in theT−H−2interval, and are transmitted to offspring fromtTu/+ males at nearly Mendelian ratios. ThetTu3haplotype resemblestTu1andtTu4except for the fact that theT/tTu3heterozygotes have normal-length tails. ThetTu2haplotype probably carries the lethal factor oftTu12tf, suppresses crossing-over in theT-H-2andtf-H-2intervals, and displays a slightly subnormal transmission ratio. In the compound heterozygotetTu1/tTu2, the male transmission ratio of thetTu1chromosome is close to that of the originaltTu12tfhaplotype. A similar effect is observed in thetTu3/tTu2heterozygote. This observation is interpreted as evidence for two regions within thetcomplex controlling the male transmission ratios. One of the regions is close to the tail-modifying region, the other is close to the lethality factor. Our findings parallel closely those made in the segregation distorter system inDrosophila.