Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

作者：Robert Visse, Hideaki Nagase · 发表于：Circulation Research · 年份：2003 · DOI：10.1161/01.res.0000070112.80711.3d · 被引用次数：4572 · 研究领域：Protease and Inhibitor Mechanisms、Signaling Pathways in Disease、Peptidase Inhibition and Analysis

Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.