Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

作者：Hang Hubert Yin, Andrew D. Hamilton · 发表于：Angewandte Chemie International Edition · 年份：2005 · DOI：10.1002/anie.200461786 · 被引用次数：452 · 研究领域：Click Chemistry and Applications、Chemical Synthesis and Analysis、Monoclonal and Polyclonal Antibodies Research

The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.