Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine

作者：E. Leong Way, Horace H. Loh, Fu-Hsiung Shen · 发表于：Science · 年份：1968 · DOI：10.1126/science.162.3859.1290 · 被引用次数：259 · 研究领域：Neurotransmitter Receptor Influence on Behavior、Neuroscience and Neuropharmacology Research、Neuroendocrine regulation and behavior

Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.