A Three‐Dimensional Bioprinting System for Use With a Hydrogel‐Based Biomaterial and Printing Parameter Characterization

作者：Seung‐Joon Song, Jaesoon Choi, Yongdoo Park, J J Lee, Soyoung Hong, Kyung Sun · 发表于：Artificial Organs · 年份：2010 · DOI：10.1111/j.1525-1594.2010.01143.x · 被引用次数：65 · 研究领域：3D Printing in Biomedical Research、Additive Manufacturing and 3D Printing Technologies、Innovative Microfluidic and Catalytic Techniques Innovation

Bioprinting is an emerging technology for constructing tissue or bioartificial organs with complex three-dimensional (3D) structures. It provides high-precision spatial shape forming ability on a larger scale than conventional tissue engineering methods, and simultaneous multiple components composition ability. Bioprinting utilizes a computer-controlled 3D printer mechanism for 3D biological structure construction. To implement minimal pattern width in a hydrogel-based bioprinting system, a study on printing characteristics was performed by varying printer control parameters. The experimental results showed that printing pattern width depends on associated printer control parameters such as printing flow rate, nozzle diameter, and nozzle velocity. The system under development showed acceptable feasibility of potential use for accurate printing pattern implementation in tissue engineering applications and is another example of novel techniques for regenerative medicine based on computer-aided biofabrication system.