Cyclic Nucleotide-Gated Ion Channels: An Extended Family With Diverse Functions

作者：John T. Finn, Maria E. Grunwald, K-W Yau · 发表于：Annual Review of Physiology · 年份：1996 · DOI：10.1146/annurev.ph.58.030196.002143 · 被引用次数：321 · 研究领域：Ion channel regulation and function、Neuroscience and Neuropharmacology Research、Cardiac electrophysiology and arrhythmias

An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.