Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms

作者：Jhon Alberto Ochoa-Alvarez, Harini Krishnan, John G. Pastorino, Evan Nevel, David J. Kephart, Joseph Jonathan Lee, Edward P. Retzbach, Yongquan Shen, Mahnaz Fatahzadeh, Soly Baredes, Evelyne Kalyoussef, Masaru Honma, Martin E. Adelson, Mika Kato Kaneko, Yukinari Kato, Mary Ann Young, Lisa Deluca-Rapone, Alan J. Shienbaum, Kingsley Yin, Lasse D. Jensen, Gary S. Goldberg · 发表于：Oncotarget · 年份：2015 · 被引用次数：87 · 研究领域：Lymphatic System and Diseases、Galectins and Cancer Biology、Glycosylation and Glycoproteins Research

// Jhon A. Ochoa-Alvarez 1 , Harini Krishnan 1 , John G. Pastorino 1 , Evan Nevel 1 , David Kephart 1 , Joseph J. Lee 1 , Edward P. Retzbach 1 , Yongquan Shen 1 , Mahnaz Fatahzadeh 2 , Soly Baredes 3 , Evelyne Kalyoussef 3 , Masaru Honma 4 , Martin E. Adelson 5 , Mika K. Kaneko 6 , Yukinari Kato 6 , Mary Ann Young 1 , Lisa Deluca-Rapone 1 , Alan J. Shienbaum 1 , Kingsley Yin 1 , Lasse D. Jensen 7 and Gary S. Goldberg 1 1 Departments of Molecular Biology, Cell Biology, and Pathology, School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA 2 Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Newark, NJ, USA 3 Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA 4 Department of Dermatology, Asahikawa Medical University, Midorigaoka-Higashi, Asahikawa, Japan 5 Medical Diagnostic Laboratories, Hamilton, NJ, USA 6 Department of Regional Innovation, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan 7 Department of Medical and Health Sciences, Linköping University, Lasarettsgatan, Ingång, Linköping, Sweden Correspondence to: Gary S. Goldberg, email: // Keywords : podoplanin, cancer, cell migration, receptor, lectin Received : October 13, 2014 Accepted : February 04, 2015 Published : March 10, 2015 Abstract Podoplanin (PDPN) is a unique transmembrane receptor that promotes tumor cell motility. Indeed, PDPN may serve as a chemotherapeutic target for primary and ...