ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

作者：Arnold J. Berk · 发表于：Annual Review of Genetics · 年份：1986 · DOI：10.1146/annurev.ge.20.120186.000401 · 被引用次数：467 · 研究领域：Virus-based gene therapy research、Viral gastroenteritis research and epidemiology、Animal Virus Infections Studies

INTRODUCTION .. .... .. ...... .. 45 THE MAJOR LATE PROMOTER ..... ...... .. .. .. .. ..... 46 THE EIB PROMOTER , .. ,', .... ........ .... ,',., 51 THE E2 EARLY PROMOTER.,,,,,,,,,,,.,,,,,,,,,,,,,.,,,,,, .,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 53 THE E3, E4, IVa2, IX, AND E2 LATE PROMOTERS .. .... .. ,, .. ... 55 THE EIA PROMOTER ..... , ..... , ..... ,..... 61 E I A TRANSACTIVATION .... ...... ...... .. ,., ........ ,.... 65 Other Viral Transactivating Proteins .. .. .... 66 Most Endogenous Genes are not Transactivated ....... ,......... 67 No Specific Promoter Element Required for Transactivation . 67 Evidence Suggests an Increase in the Amount of Limiting Transcription Factors 69 The IE Protein Stimulates Transcription in vitro .. ,,.. .... 70 FUTURE DIRECTIONS ...... ...... ......... ........ , ..... .. , .. , 72