Species dependent variability in the susceptibility of coagulase-negative staphylococci to various antimicrobial agents

作者：Kenneth V. I. Rolston, Patty Thirolf, Dah S. Ho, Gerald P. Bodey · 发表于：Journal of Antimicrobial Chemotherapy · 年份：1985 · DOI：10.1093/jac/16.5.659 · 被引用次数：13 · 研究领域：Antimicrobial Resistance in Staphylococcus、Antifungal resistance and susceptibility、Antimicrobial Peptides and Activities

The in-vitro activity of 20 beta-lactam antibiotics and vancomycin was determined against three different species of coagulase-negative-staphylococci. All isolates were susceptible to vancomycin (MIC90 3.12-6.25 mg/l) although occasional tolerance was seen. Most isolates (85%) of Staphylococcus hominis were susceptible to methicillin and other beta-lactams including cephalothin, cefapirin, cefamandole, imipenem and BMY28142, while 90% of Staph. haemolyticus isolates were resistant to these agents. Staph. epidermidis was intermediate in susceptibility with 50% of isolates being methicillin resistant (MR). These MR isolates exhibited cross-resistance or tolerance to the other beta-lactam agents except cefamandole.