Immunoglobulin isotype in the murine response to polysaccharide antigens

作者：Carlos S. Moreno, Jane Esdaile · 发表于：European Journal of Immunology · 年份：1983 · DOI：10.1002/eji.1830130317 · 被引用次数：28 · 研究领域：Immunodeficiency and Autoimmune Disorders、Blood groups and transfusion、T-cell and B-cell Immunology

Murine antisera specific for the alpha (1 leads to 3) and alpha (1 leads to 6)-linked glucosyl determinants of dextran, as well as for meningococcal polysaccharide group C, have been examined for the distribution of their immunoglobulin classes and subclasses. Whereas the thymus-independent anti-alpha (1 leads to 3) dextran response in BALB/c mice was found to be IgM greater than IgG3 greater than IgA, thus corresponding to previously published work, neither the alpha (1 leads to 6) response in its thymus-dependent or-independent form, nor the response to purified meningococcal polysaccharide, corresponded to this pattern. No preference for any of the IgG subclasses appeared for these antigens when given as thymus-independent carbohydrates. On the other hand, thymus-dependent forms of alpha (1 leads to 6) dextran showed an IgG1 greater than IgG3 greater than IgG2 pattern.