LEUKOTRIENE B4: A MEDIATOR OF VASCULAR PERMEABILITY

作者：M.A. Bray, Fiona M. Cunningham, A. W. Ford‐Hutchinson, M. J. H. Smith · 发表于：British Journal of Pharmacology · 年份：1981 · DOI：10.1111/j.1476-5381.1981.tb11000.x · 被引用次数：247 · 研究领域：Inflammatory mediators and NSAID effects、Pharmacology and Obesity Treatment、Antiplatelet Therapy and Cardiovascular Diseases

1 Intradermal injection of leukotriene B4 (LTB4) or prostaglandin E2 (PGE2), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea-pig and rat. 2 Intradermal injection of LTB4 or PGE2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea-pig. 4 LTB4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE2 which was a potent vasodilator in this species. 5 It is concluded that LTB4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE2.