Epstein‐Barr herpesvirus infection: Inhibition by immunologically induced mediators with interferon‐like properties

作者：P K Lai, P. Alpers, Ewart M. Mackay‐Scollay · 发表于：International Journal of Cancer · 年份：1977 · DOI：10.1002/ijc.2910200106 · 被引用次数：28 · 研究领域：Viral-associated cancers and disorders、Cytomegalovirus and herpesvirus research、Parvovirus B19 Infection Studies

When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited EBV-induced transformation and EBV superinfection of target cells. Unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenged with the antigens. This indicates that cell-mediated immunity and its associated soluble mediators may be involved in the control of EBV infection and that the interferon release assay is a useful in vitro correlate for the study of cellular immunity to EBV.