The Redox Potential of Selenocystine in Unconstrained Cyclic Peptides

作者：Dörthe Besse, Frank Siedler, Tammo Diercks, Horst Kessler, Luis Moroder · 发表于：Angewandte Chemie International Edition in English · 年份：1997 · DOI：10.1002/anie.199708831 · 被引用次数：146 · 研究领域：Selenium in Biological Systems、Redox biology and oxidative stress、Peptidase Inhibition and Analysis

A much lower redox potential than that of the mixed Sec,Cys-peptide and particularly of the related Cys,Cys-peptide is a feature of the cyclic selenocystine-peptide (Sec,Sec-peptide). These findings that were obtained with appropriately modified glutaredoxin-octapeptides at pH 7 [Eq. (1); X = S, Se; DTT = dithiothreitol], open interesting new approaches for the design of productive intermediates in the oxidative folding of synthetic peptides and recombinant proteins. Moreover, such seleno derivatives may represent useful heavy metal analogs for X-ray structure analysis.