Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

作者：Roberto Calcedo, Hiroki Morizono, Lili Wang, Robert McCarter, Jianping He, David Jones, Mark L. Batshaw, James M. Wilson · 发表于：Clinical and Vaccine Immunology · 年份：2011 · DOI：10.1128/cvi.05107-11 · 被引用次数：339 · 研究领域：Virus-based gene therapy research、Herpesvirus Infections and Treatments、Viral Infections and Immunology Research

Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.