The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

作者：Steven B. McMahon, Marcelo A. Wood, Michael D. Cole · 发表于：Molecular and Cellular Biology · 年份：2000 · DOI：10.1128/mcb.20.2.556-562.2000 · 被引用次数：496 · 研究领域：Signaling Pathways in Disease、Genomics and Chromatin Dynamics、Histone Deacetylase Inhibitors Research

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical and genetic pathways leading to transformation remain undefined. We demonstrate here that the recently described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5 protein. Since c-Myc function is inhibited by recruitment of histone deacetylase activity through Mad family proteins, these opposing biochemical activities are likely to be responsible for the antagonistic biological effects of c-Myc and Mad on target genes and ultimately on cellular transformation.