Toward the Cure of All Children With Cancer Through Collaborative Efforts: Pediatric Oncology As a Global Challenge

作者：Carlos Rodríguez‐Galindo, Paola Friedrich, Patricia Alcasabas, Federico Antillón, Shripad Banavali, Luis Castillo, Trijn Israëls, Sima Jeha, Mhammed Harif, Michael Sullivan, Thuan Chong Quah, Catherine Patte, Ching‐Hon Pui, Ronald D. Barr, Thomas G. Gross · 发表于：Journal of Clinical Oncology · 年份：2015 · DOI：10.1200/jco.2014.60.6376 · 被引用次数：465 · 研究领域：Childhood Cancer Survivors' Quality of Life、Acute Lymphoblastic Leukemia research、BRCA gene mutations in cancer

Advances in the treatment of childhood cancers have resulted in part from the development of national and international collaborative initiatives that have defined biologic determinants and generated risk-adapted therapies that maximize cure while minimizing acute and long-term effects. Currently, more than 80% of children with cancer who are treated with modern multidisciplinary treatments in developed countries are cured; however, of the approximately 160,000 children and adolescents who are diagnosed with cancer every year worldwide, 80% live in low- and middle-income countries (LMICs), where access to quality care is limited and chances of cure are low. In addition, the disease burden is not fully known because of the lack of population-based cancer registries in low-resource countries. Regional and ethnic variations in the incidence of the different childhood cancers suggest unique interactions between genetic and environmental factors that could provide opportunities for etiologic research. Regional collaborative initiatives have been developed in Central and South America and the Caribbean, Africa, the Middle East, Asia, and Oceania. These initiatives integrate regional capacity building, education of health care providers, implementation of intensity-graduated treatments, and establishment of research programs that are adjusted to local capacity and local needs. Together, the existing consortia and regional networks operating in LMICs have the potential to reach out t...