Critical appraisal of the accuracy of Acuros-XB and Anisotropic Analytical Algorithm compared to measurement and calculations with the compass system in the delivery of RapidArc clinical plans

作者：Murugesan Kathirvel, Shanmuga Subramanian, Alessandro Clivio, Arun Gandhi, Antonella Fogliata, Giorgia Nicolini, Vellaiyan Subramani, Shanmugam Thirumalai Swamy, Eugenio Vanetti, Luca Cozzi · 发表于：Radiation Oncology · 年份：2013 · DOI：10.1186/1748-717x-8-140 · 被引用次数：39 · 研究领域：Advanced Radiotherapy Techniques、Radiation Therapy and Dosimetry、Effects of Radiation Exposure

Abstract Background The accuracy of the two dose calculation engines available for RapidArc planning (both released for clinical use) is investigated in comparison to the COMPASS data. Methods Two dose calculation algorithms (Acuros-XB and Anisotropic Analytic Algorithm (AAA)) were used to calculate RA plans and compared to calculations with the Collapsed Cone Convolution algorithm (CC) from the COMPASS system (IBA Dosimetry). CC calculations, performed on patient data, are based on experimental fluence measurements with a 2D array of ion chambers mounted on the linac head. The study was conducted on clinical cases treated with RA. Five cases for each of the following groups were included: Brain, Head and Neck, Thorax, Pelvis and stereotactic body radiation therapy for hypo-fractionated treatments with small fields. COMPASS measurements were performed with the iMatrixx-2D array. RapidArc plans were optimized for delivery using 6MV photons from a Clinac-iX (Varian, Palo Alto, USA). Accuracy of the RA calculation was appraised by means of: 1) comparison of Dose Volume histograms (DVH) metrics; 2) analysis of differential dose distributions and determination of mean dose differences per organ; 3) 3D gamma analysis with distance-to-agreement and dose difference thresholds set to 3%/3 mm or 2%/2 mm for targets, organs at risks and for the volumes encompassed by the 50 and 10% isodoses. Results For almost all parameters, the better agreement was between Acuros-XB and COMPASS indepe...