Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4

作者：Benjamin Sadlack, Ralf Kühn, Hubert Schorle, Klaus Rajewsky, Werner Müller, Ivan David Horak · 发表于：European Journal of Immunology · 年份：1994 · DOI：10.1002/eji.1830240144 · 被引用次数：143 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、CAR-T cell therapy research

Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2 and IL-4-deficient homozygous mice.